Purpose. To investigate the potential relationship between open-angle glaucoma (OAG) and peripapillary choroidal thickness\n(PPCT). Materials and Methods. Relevant publications were searched systematically through various databases from inception\nto January 2016. Studies comparing PPCT in OAG patients and healthy controls were retrieved. All qualified articles were analyzed\nusing Stata 14.0 and Revman 5.3 software. Results. A total of 13 studies were identified for inclusion. There was a significant\nreduction of average PPCT in OAG patients compared to control participants (WMD = âË?â??24.07, 95% CI: âË?â??34.29, âË?â??13.85). Reduction\nof PPCT was significant in the superior (WMD = âË?â??28.87, 95% CI: âË?â??44.96, âË?â??12.78) and nasal (WMD = âË?â??21.75, 95% CI: âË?â??41.52,\nâË?â??1.98) sectors, but there was no significant reduction of PPCT in the inferior (WMD = âË?â??9.57, 95% CI: âË?â??36.55, 17.40) and temporal\n(WMD = âË?â??13.85, 95% CI: âË?â??35.40, 7.70) sectors. No obvious publication bias was detected. Conclusions.This meta-analysis suggests\nthat open-angle glaucoma patients have significantly decreased peripapillary choroidal thickness compared to healthy individuals.\nPeripapillary choroidal thickness measured by optical coherence tomography may be an important parameter to consider in open angle\nglaucoma.
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